Pharm 4.0 Education and
Research Team

Discovery and SAR studies of 3-amino-4-(phenylsulfonyl)tetrahydrothiophene 1,1-dioxides as non-electrophilic antioxidant response element (ARE) activators. BIOORGANIC CHEMISTRY, ACADEMIC PRESS INC ELSEVIER SCIENCE, 2021-03

권 108 페이지 104614 ~ 104619

Preparation and Evaluation of Amino Acid Conjugates of Celecoxib as Prodrugs to Improve the Pharmacokinetic and Therapeutic Properties of Celecoxib. PHARMACEUTICS, MDPI, 2020-11

권 12 호 11 페이지 1 ~ 10

A Colon-Targeted Prodrug, 4-Phenylbutyric Acid-Glutamic Acid Conjugate, Ameliorates 2,4-Dinitrobenzenesulfonic Acid-Induced Colitis in Rats. PHARMACEUTICS, MDPI, 2020-09

권 12 호 9 페이지 843 ~ 854

miR-23a-3p is a Key Regulator of IL-17C-Induced Tumor Angiogenesis in Colorectal Cancer. CELLS, MDPI, 2020-06

권 9 호 6 페이지 1363 ~ 1363

In Staphylococcus aureus, the Particulate State of the Cell Envelope Is Required for the Efficient Induction of Host Defense Responses. INFECTION AND IMMUNITY, AMER SOC MICROBIOLOGY, 2019-12

권 87 호 12 페이지 1 ~ 15

Sofalcone, a gastroprotective drug, covalently binds to KEAP1 to activate Nrf2 resulting in anti-colitic activity. EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER SCIENCE BV, 2019-12

권 865 페이지 1 ~ 12

Mesalazine activates adenosine monophosphate-activated protein kinase: Implication in the anti-inflammatory activity of this anti-colitic drug. CURRENT MOLECULAR PHARMACOLOGY, BENTHAM SCIENCE PUBL LTD, 2019-12

권 12 호 4 페이지 272 ~ 280

Conjugation of amisulpride, an anti-psychotic agent, with 5-aminosalicylic acid via an azo bond yields an orally active mutual prodrug against rat colitis. PHARMACEUTICS, MDPI, 2019-11

권 11 호 11 페이지 1 ~ 12

Colon-targeted delivery facilitates the therapeutic switching of sofalcone, a gastroprotective agent, to an anticolitic drug via Nrf2 Activation. MOLECULAR PHARMACEUTICS, AMER CHEMICAL SOC, 2019-09

권 16 호 9 페이지 4007 ~ 4016

Pro-apoptotic effect of the novel benzylidene derivative MHY695 in human colon cancer cells. ONCOLOGY LETTERS, SPANDIDOS PUBL LTD, 2019-09

권 18 호 3 페이지 3256 ~ 3264

Pharmacokinetic Evaluation of Metabolic Drug Interactions between Repaglinide and Celecoxib by a Bioanalytical HPLC Method for Their Simultaneous Determination with Fluorescence Detection. PHARMACEUTICS, MDPI, 2019-08

권 11 호 8 페이지 382 ~ 395

Colon-targeted dexamethasone microcrystals with pH-sensitive chitosan/alginate/Eudragit S multilayers for the treatment of inflammatory bowel disease. CARBOHYDRATE POLYMERS, ELSEVIER SCI LTD, 2018-10

권 198 페이지 434 ~ 442

Novel β-phenylacrylic acid derivatives exert anti-cancer activity by inducing Src-mediated apoptosis in wild-type KRAS colon cancer. CELL DEATH & DISEASE, NATURE PUBLISHING GROUP, 2018-09

권 9 호 9 페이지 1 ~ 17

Therapeutic Effect of Quinacrine, an Antiprotozoan Drug, by Selective Suppression of p-CHK1/2 in p53-Negative Malignant Cancers. MOLECULAR CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, 2018-06

권 16 호 6 페이지 935 ~ 946

Insecticidal activity of the metalloprotease AprA occurs through suppression of host cellular and humoral immunity. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, 2018-04

권 81 페이지 116 ~ 126

Colon-targeted delivery of cyclosporine A using dual-functional Eudragit (R) FS30D/PLGA nanoparticles ameliorates murine experimental colitis. INTERNATIONAL JOURNAL OF NANOMEDICINE, DOVE MEDICAL PRESS LTD, 2018-02

권 13 페이지 1225 ~ 1240

Minoxidil Induction of VEGF Is Mediated by Inhibition of HIF-Prolyl Hydroxylase. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL, 2018-01

권 19 호 1 페이지 1 ~ 14

Oxidized 5-aminosalicylic acid activates Nrf2-HO-1 pathway by covalently binding to Keap1: Implication in anti-inflammatory actions of 5-aminosalicylic acid. FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 2017-07

권 108 페이지 715 ~ 724

Conjugation of metronidazole with dextran: a potential pharmaceutical strategy to control colonic distribution of the anti-amebic drug susceptible to metabolism by colonic microbes. DRUG DESIGN DEVELOPMENT AND THERAPY, Dove Medical Press, 2017-02

권 11 페이지 419 ~ 429

Rebamipide induces the gastric mucosal protective factor, cyclooxygenase-2, via activation of 5 '-AMP-activated protein kinase. Biochemical and Biophysical Research Communications 441(4), ACADEMIC PRESS INC ELSEVIER SCIENCE, 2017-01

권 483 호 1 페이지 449 ~ 455

Targeting ASC in NLRP3 inflammasome by caffeic acid phenethyl ester: a novel strategy to treat acute gout. SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, 2016-12

권 6 페이지 38622 ~ 38630

Increased therapeutic efficacy of a newly synthesized tyrosinase inhibitor by solid lipid nanoparticles in the topical treatment of hyperpigmentation. DRUG DESIGN DEVELOPMENT AND THERAPY, Dove Medical Press, 2016-12

권 10 페이지 3947 ~ 3957

Herceptin-functionalized pure paclitaxel nanocrystals for enhanced delivery to HER2-postive breast cancer cells. INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER SCIENCE BV, 2016-11

권 513 호 1-2 페이지 543 ~ 553

Effects of Lizhong Tang on gastrointestinal motility in mice. WORLD JOURNAL OF GASTROENTEROLOGY, W J G PRESS, 2016-09

권 22 호 34 페이지 7778 ~ 7786

5-Aminosalicylic Acid Azo-Linked to Procainamide Acts as an Anticolitic Mutual Prodrug via Additive Inhibition of Nuclear Factor kappaB. MOLECULAR PHARMACEUTICS, AMER CHEMICAL SOC, 2016-06

권 13 호 6 페이지 2126 ~ 2135

Dextran-5-(4-ethoxycarbonylphenylazo)salicylic acid ester, a polymeric colon-specific prodrug releasing 5-aminosalicylic acid and benzocaine, ameliorates TNBS-induced rat colitis. JOURNAL OF DRUG TARGETING, TAYLOR & FRANCIS LTD, 2016-05

권 24 호 5 페이지 468 ~ 474

A specific cathepsin-L-like protease purified from an insect midgut shows antibacterial activity against gut symbiotic bacteria. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, 2015-11

권 53 호 1 페이지 79 ~ 84

Colonic delivery of celecoxib is a potential pharmaceutical strategy for repositioning the selective COX-2 inhibitor as an anti-colitic agent. ARCHIVES OF PHARMACAL RESEARCH, 대한약학회, 2015-10

권 38 호 10 페이지 1830 ~ 1838

Design, synthesis, and anti-melanogenic effects of (E)-2-benzoyl-3-(substituted phenyl)acrylonitriles. DRUG DESIGN DEVELOPMENT AND THERAPY, Dove Medical Press, 2015-08

권 9 호 0 페이지 4259 ~ 4268

Development of megestrol acetate solid dispersion nanoparticles for enhanced oral delivery by using a supercritical antisolvent process. DRUG DESIGN DEVELOPMENT AND THERAPY, Dove Medical Press, 2015-08

권 9 페이지 4269 ~ 4277

Evaluation of glycine-bearing celecoxib derivatives as a colon-specific mutual prodrug acting on nuclear factor-kappa B, an anti-inflammatory target. DRUG DESIGN DEVELOPMENT AND THERAPY, Dove Medical Press, 2015-08

권 9 페이지 4227 ~ 4237

Colon-targeted delivery of piceatannol enhances anti-colitic effects of the natural product: potential molecular mechanisms for therapeutic enhancement. DRUG DESIGN DEVELOPMENT AND THERAPY, Dove Medical Press, 2015-08

권 9 페이지 4247 ~ 4258

Celecoxib coupled to dextran via a glutamic acid linker yields a polymeric prodrug suitable for colonic delivery. DRUG DESIGN DEVELOPMENT AND THERAPY, Dove Medical Press, 2015-08

권 9 페이지 4105 ~ 4113

Colon-targeted delivery of budesonide using dual pH- and time-dependent polymeric nanoparticles for colitis therapy. DRUG DESIGN DEVELOPMENT AND THERAPY, Dove Medical Press, 2015-07

권 9 호 0 페이지 3789 ~ 3799

Enhanced therapeutic efficacy of budesonide in experimental colitis with enzyme/pH dual-sensitive polymeric nanoparticles. INTERNATIONAL JOURNAL OF NANOMEDICINE, DOVE MEDICAL PRESS LTD, 2015-07

권 10 호 0 페이지 4565 ~ 4580

Improving dissolution and oral bioavailability of pranlukast hemihydrate by particle surface modification with surfactants and homogenization. DRUG DESIGN DEVELOPMENT AND THERAPY, Dove Medical Press, 2015-06

권 9 호 0 페이지 3257 ~ 3266

Design of a gelatin microparticle-containing self-microemulsifying formulation for enhanced oral bioavailability of dutasteride. DRUG DESIGN DEVELOPMENT AND THERAPY, Dove Medical Press, 2015-06

권 9 호 0 페이지 3231 ~ 3238

HIF-prolyl hydroxylase is a potential molecular target for esculetin-mediated anti-colitic effects. FITOTERAPIA, ELSEVIER SCIENCE BV, 2015-06

권 103 호 0 페이지 55 ~ 62

"Nitric oxide-releasing poly(lactic-co-glycolic acid)-polyethylenimine nanoparticles for prolonged nitric oxide release, antibacterial efficacy, and in vivo wound healing activity". INTERNATIONAL JOURNAL OF NANOMEDICINE, DOVE MEDICAL PRESS LTD, 2015-04

권 10 페이지 3065 ~ 3080

Lipophilic modification enhances anti-colitic properties of rosmarinic acid by potentiating its HIF-prolyl hydroxylases inhibitory activity. EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER SCIENCE BV, 2015-01

권 747 페이지 114 ~ 122

Phospholipase D1 protein coordinates dynamic assembly of HIF-1 alpha-PHD-VHL to regulate HIF-1 alpha stability. ONCOTARGET, IMPACT JOURNALS LLC, 2014-12

권 5 호 23 페이지 11857 ~ 11872

Phospholipase D activates HIF-1-VEGF pathway via phosphatidic acid. EXPERIMENTAL AND MOLECULAR MEDICINE, 대한생화학.분자생물학회, 2014-12

권 46 페이지 1 ~ 7

Enzyme/pH dual sensitive polymeric nanoparticles for targeted drug delivery to the inflamed colon. COLLOIDS AND SURFACES B-BIOINTERFACES, ELSEVIER SCIENCE BV, 2014-11

권 123 호 0 페이지 271 ~ 278

Colon-targeted celecoxib ameliorates TNBS-induced rat colitis: A potential pharmacologic mechanism and therapeutic advantages. EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER SCIENCE BV, 2014-03

권 726 페이지 49 ~ 56

Dithiocarbamate chitosan as a potential polymeric matrix for controlled drug release. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, MARCEL DEKKER INC, 2014-02

권 40 페이지 192 ~ 200

N-(2-mercaptopropionyl)-glycine, a diffusible antioxidant, activates HIF-1 by inhibiting HIF prolyl hydroxylase-2: Implication in amelioration of rat colitis by the antioxidant. Biochemical and Biophysical Research Communications 441(4), ACADEMIC PRESS INC ELSEVIER SCIENCE, 2014-01

권 443 호 3 페이지 1008 ~ 1013

Caffeic acid phenethyl ester activation of Nrf2 pathway is enhanced under oxidative state: Structural analysis and potential as a pathologically targeted therapeutic agent in treatment of colonic inflammation. FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 2013-12

권 65 페이지 552 ~ 562

Loss of VHL promotes progerin expression, leading to impaired p14/ARF function and suppression of p53 activity. CELL CYCLE, LANDES BIOSCIENCE, 2013-07

권 12 호 14 페이지 2277 ~ 2290

Development of Akt-activated GSK3 beta inhibitory peptide. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, 2013-05

권 434 호 4 페이지 735 ~ 739

Glycyrrhizin Enhances Therapeutic Activity of a Colon-Specific Methylprednisolone Prodrug Against Experimental Colitis. DIGESTIVE DISEASES AND SCIENCES, SPRINGER, 2013-05

권 58 호 5 페이지 1226 ~ 1234

Senescence marker protein 30 deficiency increases Parkinson's pathology by impairing astrocyte activation. NEUROBIOLOGY OF AGING, ELSEVIER SCIENCE INC, 2013-04

권 34 호 4 페이지 1177 ~ 1183

Piceatannol, a hydroxystilbene natural product, stabilizes HIF-1 alpha protein by inhibiting HIF prolyl hydroxylase. EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER SCIENCE BV, 2013-01

권 699 호 1-3 페이지 124 ~ 131

A novel lipid nanoemulsion system for improved permeation of granisetron. COLLOIDS AND SURFACES B-BIOINTERFACES, ELSEVIER SCIENCE BV, 2013-01

권 101 페이지 475 ~ 480

Colon-specific delivery of celecoxib is a potential strategy to improve toxicological and pharmacological properties of the selective Cox-2 inhibitor: implication in treatment of familiar adenomatous polyposis. JOURNAL OF DRUG TARGETING, TAYLOR & FRANCIS LTD, 2012-07

권 20 호 6 페이지 524 ~ 534

Anti-tumor Activity of the Novel Hexahydrocannabinol Analog LYR-8 in Human Colorectal Tumor Xenograft Is Mediated through the Inhibition of Akt and Hypoxia-Inducible Factor-1 alpha Activation. BIOLOGICAL PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, 2012-06

권 35 호 6 페이지 924 ~ 932

Preparation and in vitro evaluation of celecoxib-amino acid conjugates as a colon specific prodrug. Journal of Pharmaceutical Investigation, 한국약제학회, 2012-06

권 42 호 03 페이지 115 ~ 120

Anti-tumor Activity of the Novel Hexahydrocannabinol Analog LYR-8 in Human Colorectal Tumor Xenograft Is Mediated through the Inhibition of Akt and Hypoxia-Inducible Factor-1 alpha Activation. BIOLOGICAL PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, 2012-06

권 35 호 6 페이지 924 ~ 932

Colon-Targeted Cell-Permeable NF kappa B Inhibitory Peptide Is Orally Active against Experimental Colitis. MOLECULAR PHARMACEUTICS, AMER CHEMICAL SOC, 2012-05

권 9 호 5 페이지 1310 ~ 1319

N-Succinylaspart-1-yl Celecoxib is a Potential Colon-Specific Prodrug of Celecoxib with Improved Therapeutic Properties. JOURNAL OF PHARMACEUTICAL SCIENCES, JOHN WILEY & SONS INC, 2012-05

권 101 호 5 페이지 1831 ~ 1842

Synthesis and evaluation of sulfate conjugated metronidazole as a colon-specific prodrug of metronidazole. JOURNAL OF DRUG TARGETING, TAYLOR & FRANCIS LTD, 2012-04

권 20 호 3 페이지 255 ~ 263

Susceptibility of glucocorticoids to colonic metabolism and pharmacologic intervention in the metabolism: Implication for therapeutic activity of colon-specific glucocorticoid 21-sulfate sodium at the target site. JOURNAL OF PHARMACY AND PHARMACOLOGY, ROYAL PHARMACEUTICAL SOC GREAT BRITAIN, 2012-01

권 64 호 1 페이지 128 ~ 138

Structure-activity relationship of salicylic acid derivatives on inhibition of TNF-α dependent NFκB activity: Implication on anti-inflammatory effect of N-(5-chlorosalicyloyl)phenethylamine against experimental colitis. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2011-11

권 46 페이지 1 ~ 9

Structural effects of N-aromatic acyl-amino acid conjugates on their deconjugation in the cecal contents of rats: implication in design of a colon-specific prodrug with controlled conversion rate at the target site. BIOPHARMACEUTICS & DRUG DISPOSITION, JOHN WILEY & SONS LTD, 2011-09

권 32 호 6 페이지 343 ~ 354

Hyperoxia attenuates the inhibitory effect of nitric oxide donors on HIF prolyl-4-hydroxylase-2: Implication on discriminative effect of nitric oxide on HIF prolyl-4-hydroxylase-2 and collagen prolyl-4-hydroxylase. BIOCHEMICAL PHARMACOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, 2011-09

권 82 호 5 페이지 485 ~ 490

Evaluation of dextran-flufenamic acid ester as a polymeric colon-specific prodrug of flufenamic acid, an anti-inflammatory drug, for chronotherapy. JOURNAL OF DRUG TARGETING, TAYLOR & FRANCIS LTD, 2011-06

권 19 호 5 페이지 336 ~ 343

NRF2 Blockade Suppresses Colon Tumor Angiogenesis by Inhibiting Hypoxia-Induced Activation of HIF-1 alpha. CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, 2011-03

권 71 호 6 페이지 2260 ~ 2275

키토산을 지지체로 이용한 고분자성 항균제 개발에 관한 연구. Journal of Chitin and Chitosan, 한국키틴키토산학회, 2010-12

권 15 호 4 페이지 216 ~ 222

Emetine Promotes von Hippel-Lindau-Independent Degradation of Hypoxia-Inducible Factor-2 alpha in Clear Cell Renal Carcinoma. MOLECULAR PHARMACOLOGY, AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS, 2010-12

권 78 페이지 1072 ~ 1078

von Hippel-Lindau beta-domain-luciferase fusion protein as a bioluminescent hydroxyproline sensor for a hypoxia-inducible factor prolyl hydroxylase assay. ANALYTICAL BIOCHEMISTRY, ACADEMIC PRESS INC ELSEVIER SCIENCE, 2010-12

권 407 호 2 페이지 220 ~ 225

Caffeic acid phenethyl ester-mediated Nrf2 activation and I kappa B kinase inhibition are involved in NF kappa B inhibitory effect: Structural analysis for NF kappa B inhibition. EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER SCIENCE BV, 2010-09

권 643 호 1 페이지 21 ~ 28

Caffeic acid phenethyl ester is a potent inhibitor of HIF prolyl hydroxylase: structural analysis and pharmacological implication. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, ELSEVIER SCIENCE INC, 2010-09

권 21 호 9 페이지 809 ~ 817

Structural Analysis of 5-aminosalicyl-L-glutamic Acid, a Colon-specific Prodrug of 5-aminosalicylic Acid, for Colon-specific Deconjugation. 한국산학기술학회논문지제11권제2호, 한국산학기술학회, 2010-08

권 40 호 4 페이지 213 ~ 218

Melatonin suppresses tumor angiogenesis by inhibiting HIF-1 alpha stabilization under hypoxia. JOURNAL OF PINEAL RESEARCH, BLACKWELL MUNKSGAARD, 2010-03

권 48 호 2 페이지 178 ~ 184

What should be considered on design of a colon-specific prodrug?. EXPERT OPINION ON DRUG DELIVERY, Informahealth, 2010-02

권 7 페이지 245 ~ 258

Synthesis and evaluation of N-nicotinoyl-2-{2-(2-methyl-5-nitroimidazol-1-yl)ethyloxy}-D,L-glycine as a colon-specific prodrug of metronidazole.. JOURNAL OF PHARMACEUTICAL SCIENCES, JOHN WILEY & SONS INC, 2009-11

권 98 페이지 4161 ~ 4169

An anti-inflammatory mechanism of taurine conjugated 5-aminosalicylic acid against experimental colitis: Taurine chloramine potentiates inhibitory effect of 5-aminosalicylic acid on IL-1β-mediated NFκB activation. EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER SCIENCE BV, 2009-09

권 618 호 1-3 페이지 91 ~ 97

Sulfate-conjugated methylprednisolone as a colon-targeted methylprednisolone prodrug with improved therapeutic properties against rat colitis. JOURNAL OF DRUG TARGETING, TAYLOR & FRANCIS LTD, 2009-07

권 17 페이지 450 ~ 458

Manganese (II) induces chemical hypoxia by inhibiting HIF-prolyl hydroxylase: Implication in manganese-induced pulmonary inflammation. TOXICOLOGY AND APPLIED PHARMACOLOGY, ACADEMIC PRESS INC ELSEVIER SCIENCE, 2009-03

권 235 호 3 페이지 261 ~ 267

Dexamethasone 21-sulfate improves the therapeutic properties of dexamethasone against experimental rat colitis by specifically delivering the steroid to the large intestine.. PHARMACEUTICAL RESEARCH, KLUWER ACADEMIC/PLENUM PUBL, 2009-02

권 26 페이지 415 ~ 421

Sulfate-conjugated methylprednisolone: Evaluation as a colon-specific methylprednisolone prodrug and comparison with sulfate-conjugated prednisolone and dexamethasone. JOURNAL OF DRUG TARGETING, TAYLOR & FRANCIS LTD, 2009-02

권 17 페이지 159 ~ 167

N,N '-Bis(5-aminosalicyl)-L-Cystine Is a Potential Colon-Specific 5-Aminosalicylic Acid Prodrug with Dual Therapeutic Effects in Experimental Colitis. JOURNAL OF PHARMACEUTICAL SCIENCES, JOHN WILEY & SONS INC, 2009-01

권 98 페이지 159 ~ 168

Synthesis and properties of N,N'-bis(5-aminosalicyl)-L-cystine as a colon-specific deliverer of 5-aminosalicylic acid and cystine. DRUG DELIVERY, TAYLOR & FRANCIS INC, 2008-01

권 15 페이지 37 ~ 42

Evaluation of cellulose xanthate-metal-tetracycline complexes as a polymeric antibacterial agent with prolonged antibacterial activity. DRUG DELIVERY, TAYLOR & FRANCIS INC, 2008-01

권 15 페이지 31 ~ 35

Quercetin activates an angiogenic pathway, hypoxia inducible factor (HIF)-1-vascular endothelial growth factor, by inhibiting HIF-prolyl hydroxylase: a structural analysis of quercetin for inhibiting HIF-prolyl hydroxylase. MOLECULAR PHARMACOLOGY, AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS, 2007-06

권 71 페이지 1676 ~ 1684

Synthesis and properties of N-nicotinoyl-2-(5-fluorouracil-1-yl)-D,L-glycine ester as a prodrug of 5-fluorouracil for rectal administration. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE BV, 2007-05

권 66 페이지 260 ~ 267

Synthesis and in vitro evaluation of N-nicotinoylglycyl-2-(5-fluorouracil-1-yl)-D,L-glycine as a colon-specific prodrug of 5-fluorouracil. JOURNAL OF DRUG TARGETING, TAYLOR & FRANCIS LTD, 2007-04

권 15 페이지 199 ~ 205

ErbB2 kinase domain is required for ErbB2 association with β-catenin. 생명과학회지(Journal of Life Science), 한국생명과학회, 2007-03

권 17 호 3 페이지 356 ~ 361

Curcumin-induced degradation of ErbB2: A role for the E3 ubiquitin ligase CHIP and the Michael reaction acceptor activity of curcumin. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, ELSEVIER SCIENCE BV, 2007-03

권 1773 페이지 383 ~ 390

곤충세포에서 새로운 퓨전 단백질인 초파리 유래 PGRP-LB를 이용한 인간 PTK6의 과발현 및 생산. 생명과학회지(Journal of Life Science), 한국생명과학회, 2007-01

권 17 호 2 페이지 179 ~ 184

In vitro evaluation of dextran-5-aminosalicylic acid conjugate as a polymeric colon-specific prodrug of 5-aminosalicylic acid,. 약제학회지(Journal of Korean Pharmaceutical Sciences), 한국약제학회, 2007-01

권 37 호 1 페이지 145 ~ 149

A polymeric antibacterial agent with sustained anti-bacterial activity: Cellulose xanthate-metal-neomycin complexes,. 약제학회지(Journal of Korean Pharmaceutical Sciences), 한국약제학회, 2006-12

권 36 호 6 페이지 371 ~ 375

Evaluation of 5-aminosalicyltaurine as a colon-specific prodrug of 5-aminosalicylic acid for treatment of experimental colitis. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, ELSEVIER SCIENCE BV, 2006-05

권 28 페이지 26 ~ 33

A molecular mechanism for the anti-inflammatory effect of taurine-conjugated 5-aminosalicylic acid in inflamed colon. MOLECULAR PHARMACOLOGY, AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS, 2006-04

권 69 페이지 1405 ~ 1412

Synthesis and in vitro properties of dexamethasone 21-sulfate sodium as a colon-specific prodrug of dexamethasone. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, MARCEL DEKKER INC, 2006-03

권 32 페이지 389 ~ 397

Metabolic and pharmacological properties of rutin, a dietary quercetin glycoside, for treatment of inflammatory bowel disease.. PHARMACEUTICAL RESEARCH, PLENUM PUBLISHERS, 2005-09

권 22 호 9 페이지 1499 ~ 1509

Metabolic and pharmacological properties of rutin, a dietary quercetin glycoside, for treatment of inflammatory bowel disease. PHARMACEUTICAL RESEARCH, KLUWER ACADEMIC/PLENUM PUBL, 2005-09

권 22 페이지 1499 ~ 1509

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability. CANCER CELL, CELL PRESS, 2005-08

권 8 페이지 143 ~ 153

A molecular mechanism for the anti-inflammatory effect of taurine-conjugated 5-aminosalicylic Acid in inflamed colon.. MOLECULAR PHARMACOLOGY, AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS, 2005-04

권 69 호 4 페이지 1405 ~ 1412

Apoptosis Induced by Adenovirus-mediated p14ARF Expression in U2OS Osteosarcoma Cells is Associated with Increased Fas Expression.. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, 2004-07

권 320 호 1 페이지 138 ~ 144

The effect of BSA on the release of cefadroxil from a polycaprolactone matrix.Apoptosis Induced by Adenovirus-mediated p14ARF Expression in U2OS Osteosarcoma Cells is Associated with Increased Fas Expression.. 약제학회지, 한국약제학회, 2004-05

권 34 호 5 페이지 363 ~ 368

Aryl hydrocarbon nuclear translocator (ARNT) promotes oxygen-independent stabilization of hypoxia-inducible factor-1 alpha by modulating an Hsp90-dependent regulatory pathway. JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2004-04

권 279 호 16 페이지 16128 ~ 16135

The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells. CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, 2003-11

권 63 호 22 페이지 7777 ~ 7784

IL-1 beta mediated up-regulation of HIF-1 alpha via an NFkB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, 2003-09

권 17 호 12 페이지 2115 ~ 2115

Prednislone 21-sulfate sodium: A colon-specific prodrug of prednisolone. JOURNAL OF PHARMACY AND PHARMACOLOGY, ROYAL PHARMACEUTICAL SOC GREAT BRITAIN, 2003-08

권 55 페이지 1075 ~ 1082

Synthesis and in vitro properties of prednislone 21-sulfate sodium as a colon-specific prodrug of prednisolone. Arch Pharm Res, 대한약학회, 2003-04

권 26 호 4 페이지 258 ~ 263

Synthesis and properties of 5-aminosalicyl-taurine as a colon-specific prodrug of 5-aminosalicylic acid. Arch Pharm Res, 대한약학회, 2003-04

권 26 호 4 페이지 264 ~ 269

Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor kappa B activation. JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2003-03

권 370 페이지 1011 ~ 1017

Microtubule disruption utilizes an NF kappa B-dependent pathway to stabilize HIF-1 alpha protein. JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2003-02

권 278 호 9 페이지 7445 ~ 7452

Effect of structure on the bioactivation of N-aromatic acyl-amino acid conjugates by the rat cecal contents. 약학연구지, 부산대학교 신약개발연구소, 2002-12

권 36 호 2 페이지 23 ~ 28

Symthesis and evaluation of N-acyl-2-(5-fluorouracil-1-yl)-D,L-glycine as a colon-specific prodrug of 5-fluorouracil.. J.Pharm. Sci., 미국약학회, 2001-11

권 90 호 11 페이지 1787 ~ 1794

Colon-specific prodrugs of 5-aminosalicylic acid: Synthesis and in vitro/in vivo properties of acidic amino acid derivatives of 5-aminosalicylic acid. J. pharm. Sci., 미국약학회, 2001-11

권 90 호 11 페이지 1767 ~ 1775

Synthesis and Properties of Dextran-Nalidixic Acid Ester as a Colon-Specific Prodrug of Nalidixic Acid.. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, MARCEL DEKKER INC, 2001-04

권 27 호 4 페이지 331 ~ 336

Synthesis and Properties of Dextran-linked Ampicillin . DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, MARCEL DEKKER INC, 2001-01

권 27 호 1 페이지 35 ~ 41

Cotton Fabrics with Prolonged Antibacterial Activity: Formation and Properties of Cotton Xanthate-Al(Ⅲ)-Tetracycline Complex. J. of bioactive and compatible Polymers, 미국고분자학회, 2000-09

권 15 페이지 425 ~ 437

Formation, Properties and Antimicrobial Activities of Cotton Xanthate-Cu(II)-Metronidazole Complex. Textile Res. J, Textile Reseach Institute, 2000-07

권 70 호 7 페이지 641 ~ 645

Synthesis and in vitro/in vivo evaluation of 5-aminosalicyl-glycine as a colon-specific prodrug of 5-aminosalicylic acid. J. Pharm. Sci, 미국약학회, 2000-05

권 89 호 5 페이지 594 ~ 602

Formation and properties of Cotton xanthate-Cu(II)-homosulfamine complex. 약학연구지, 부산대학교 신약개발연구소, 1999-12

권 21 호 5 페이지 570 ~ 575

Synthesis and Properties of Disodium Tetraethyleneglycol-bis-(a-Carboxybenzylpenicillin). DDIP, APHA, 1999-04

권 27 호 1 페이지 97 ~ 101

Formation, Properties and Antimicrobial Activities of Cotton Xanthate-Cu(II)-Homosulfamine Complex. Arch. Pharm. Res., 대한약학회, 1998-10

권 21 호 5 페이지 570 ~ 575

Synthesis and Properties of Dextran-5-Aminosalicylic Acid Ester as a Potential Colon-specific Prodrugs of 5-Aminosalicylic Acid. Arch. Pharm. Res.,, 대한약학회, 1998-03

권 21 호 2 페이지 179 ~ 186

Synthesis and Evaluation of 5-Aminosalicyl-glycine as a Potential Colon-specific Prodrug of 5-Aminosalicylic Acid. Arch. Pharm. Res., 대한약학회, 1998-03

권 21 호 2 페이지 174 ~ 178

Synthesis and Properties of 5-Aminosalicyl-L-Aspartic Acid and 5-Aminosalicyl-L-glutamic Acid as Colon-specific Prodrugs of 5-Aminosalicylic Acid. 약학회지, 대한약학회, 1998-01

권 42 호 1 페이지 5 ~ 11

Dextran-5-(4-ethoxycarbonylphenylazo)salicylic Acid Ester as a Colon-specific Prodrug of 5-Aminosalicylic Acid. 약학회지, 대한약학회, 1998-01

권 42 호 1 페이지 31 ~ 38

항균성 면섬유의 개발:Cotton xanthate-Cu(II)-Tetracycline complex의 생성, 성상 및 항균성. 약학연구지, 부산대학교 신약개발연구소, 1996-06

권 30 호 1 페이지 11 ~ 18